Understanding Genesis Mission Core Components
The Genesis Mission was launched by the Department of Energy seven months ago to propel the nation forward into the realm of AI for science and engineering. The mission is currently underway, and the nation’s top scientists at National Labs, universities, and the private sector are working on projects. Headed by the DOE’s Undersecretary for Science Darío Gil, the Genesis Mission has multiple pieces, some of which are in place and some of which are being built and coming online as we write this.
Department of Energy’s Undersecretary of Science Darío Gil spoke to HPCwire in February
Here are the main components of the Genesis Mission:
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- American Science and Security Platform (ASSP) – The ASSP is the overarching program within Genesis Mission that provides the centralized digital and physical infrastructure across all 17 DOE National Labs. DOE announced $320 million in funding for the ASSP last December. The ASSP includes the various new supercomputers that the DOE has announced, including Discovery and Lux, which the DOE announced last October and will go into Oak Ridge National Laboratory; and Equinox and Solstice, which also were announced in October and will go into Argonne National Lab. You can read more about the ASSP here.
- American Science Cloud (AmSC) – The AmSC is the secure, integrated cloud environment that links the DOE supercomputers, facilities, and AI systems that are part of the ASSP platform. While it was formally announced before Genesis Mission (like the new DOE supercomputers discussed above), it been incorporated into the Genesis Mission. Much of the work on AmSC, which received $40 million in funding from the DOE for 2026, is being spearheaded by Oak Ridge National Lab. You can read more about it here.
- Transformational AI Models Consortium (ModCon) – ModCon is an effort to curate existing scientific data from the national labs for AI, to create new data for AI, and to create AI models that advance AI for science and engineering efforts. ModCom was launched with $30 million in funding by the DOE for 2026, and is being led by Argonne National Lab along with PNNL.
Beyond these main components, the DOE has announced dozens of challenges and projects that are part of Genesis Mission, including 14 DOE-led robotics projects, 26 National Science and Technology Challenges, and more broadly, 37 Foundational AI awards, which were announced December 10, 2025 as part of the DOE’s $320 million funding for fiscal 2026.
Discovery is a leadership-class machine that is slated to go into Oak Ridge by 2029
- Robotics and Automation — The DOE has identified 14 projects in the area of robotics and automated laboratories to bring into the Gensis Mission. Projects include Orchestrated Platform for Autonomous Laboratories (OPAL), a four-lab project headed by PNNL that’s tasked with utilizing AI agents and robotic hardware to automate the “design-build-test-learn” cycle, with a focus on biological science and engineering; Autonomous Characterization of Materials Across Scales (ACMAS), a new project targeting the modernization of nuclear materials that’s headed by PNNL; and Synergistic Neutron and Photon Autonomous Science – Imaging (SYNAPS-I), a Lawrence Berkeley Lab project to accelerate autonomous imaging and data analysis; among others.
- National Science and Technology Challenges — In February, the DOE announced 26 primary National Science and Technology Challenges as part of Genesis Mission. The 26 challenges target specific problems, such as discovering quantum algorithms, optimizing building construction, and scaling the electrical grid. You can read more about them here.
- Foundational AI Awards — The DOE has identified 37 Foundational AI Awards that are focused on data and model development. You can read the full list of awards here.
Beyond these core Genesis Mission components and projects, there are various internal teams described by DOE as critical to the mission. There is also the Genesis Mission Consortium, as well as closely aligned third-party groups, such as the Trillion Parameter Consortium. These include:
- The Genesis Mission Data Team is a specialized group within DOE and the National Nuclear Security Administration (NNSA) responsible for curating, connecting, and securing scientific data.
Image courtesy DOE
- The Genesis Mission Models Team is responsible for delivering a portfolio of AI models, agents, and tools for use across HPC, experimental facilities, and production environments.
- The Gensis Mission Infrastructure Team delivers the software and hardware infrastructure for the ASSP platform sitting across 17 DOE labs and NNSA facilities.
- The Genesis Mission Consortium is a public-private partnership focused on advancing AI-driven scientific discovery and innovation unveiled by the DOE in February. The consortium will be operated and administered by TechWerx. You can learn more about it here.
- Trillion Parameter Consortium is an independent group that is aligned with Genesis Mission and has received DOE funding. Undersecretary Gil will be keynoting the group’s upcoming all-hands meeting and conference, TPC26, which takes place May 31 through June 3 in Baltimore, Maryland.
The DOE is moving forward with Genesis Mission projects. The deadline for Phase 1 projects, which can result in up to $750,000 in research funding over nine months, was last week. Interested parties have another two weeks to submit their applications for Phase 2 projects, which are more involved and can range up to $15 million over three years. For a full list of the DOE’s informational webinars for Genesis Mission, click here.
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